This finding is substantiated by lower IGF-1 and higher IGFBP-1 AUC values in T1DM girls from 8:00 to 10:00 a.m. (778.6 ± 232.3 ng/dl IGF-1 and 169.7 ± 84.4 ng/dl IGFBP-1 T1DM versus 954.8 ± 198.9 ng/dl IGF-1 and 79.5 ± 46.3 ng/dl IGFBP-1 controls; p ≤ 0.05). The gene discussed is IGFBP1; the disease is type 1 diabetes mellitus.