CDKN1B and neoplasm: In fact, cyclin D1 and c-Myc which are key participants in the cell-cycle pathway are frequently overexpressed in epithelial ovarian carcinomas, but they are not correlated with a particular histologic subtype [27] and p27KIP1 subcel-lular location in the cytoplasm was independently associated with poorer survival among women with ovarian carcinoma, particularly for those with late-stage disease and regardless of tumor histotype[28].