Mean and median p16 expression values for HPV-positive endocervical adenocarcinomas were substantially higher than those for primary ovarian mucinous and endometrioid tumors, HPV-unrelated endocervical adenocar-cinomas, metastatic adenocarcinomas of unknown origin, and adenocarcinomas of uncertain (primary ovarian vs. me-tastatic) origin. This evidence concerns the gene CDKN2A and adenocarcinoma.