Several studies have pointed out a relation between PrP amino acid sequence (i.e. PRNP genotype) and PrPres glycosylation in inherited diseases associated to mutation located close to (D178N, V180I, T183A, E200K) or remote (P102L) from the N-glycosylation sites [18], [19]. The gene discussed is PRNP; the disease is hereditary disease.