Importantly, enzastaurin has a cooperative effect with gefitinib and is able to overcome and revert the resistance to gefitinib in cancer cells resistant to this anti-EGFR drug, likely due to the ability of enzastaurin to inhibit the Akt and VEGF pathways, directly responsible for the escape mechanisms activated in tumours resistant to EGFR inhibitors. This evidence concerns the gene EGFR and neoplasm.