EDN1 and atherosclerosis: Furthermore, it has previously reported that EGFR is present on rabbit peripheral blood leucocytes, and co-localises with macrophages within lesions of atherosclerosis in the cholesterol-fed rabbit [40], which mediates both chemotactic responses towards monocytes and mitogenic responses towards monocyte-derived macrophages in vitro. Transactivation of the EGFR mediates endothelin-1 (a powerful vasoconstrictor, involving in vasospastic diseases such as coronary artery disease) signaling in vascular smooth muscle cells and isolated arteries [41].