In contrast to the effect of U0126, CaPs in embryos exposed to SB203580 had the same neurotransmitter (Figure 9d–d"; Table 5) and axonal (Figure 9h; Table 3) phenotype as control CaPs, suggesting that signaling via p38 and Akt is not involved in regulating CaP neurotransmitter and axon phenotype. This evidence concerns the gene CAPS and cryopyrin-associated periodic syndrome.