Smad4 increased basal and/or TGFβ-induced expression of LM-332 in Smad4-reexpressing colon and pancreatic cancer cells leading to a huge increase in the extracellular release of the heterotrimer and to the deposition in BM-like structures at contact sites with fibroblasts [19]. Here, SMAD4 is linked to familial pancreatic carcinoma.