We also observe uncoupled responses of the three LM-332 genes to TNFα in Smad4-deficient but not in Smad4-positive tumor cells (Zboralski et al., in preparation) suggesting that loss of Smad4 may also contribute to uncoupled regulation of LM-332 and consequently to an intracellular accumulation of the γ2-chain. This evidence concerns the gene SMAD4 and neoplasm.