The IgG subclasses, IgG1, IgG2 and IgG3 for MSP3, MSP119, GLURP and IgG4 to MSP3 were associated with a reduced risk of malaria in un-adjusted analysis but of these only IgG1 to MSP119 was independently associated with malaria incidence after adjustment for age. Here, IGHG3 is linked to malaria.