INS and cardiovascular disorder: Similarly, extrapolating the data from a meta-analysis of studies on insulin concentrations and risk of cardiovascular disease also suggests a potential 8% reduction in cardiovascular disease risk of the supplemented children.36 Although these improvements are substantial in themselves, even more important is the potential for these risk factors to interact with the behavioural risk factors in adulthood, resulting in a major amplification in the risk difference.1, 34