Genetic studies have also greatly contributed to corroborate the role of PPARG in the pathogenesis of metabolic syndrome related phenotypes: the Pro12Ala polymorphism of PPARG gene has been confirmed to be associated with greater body mass index (BMI) and insulin sensitivity in the obese subgroup in a recent meta-analysis with more than 32.000 individuals[10]. The gene discussed is PPARG; the disease is metabolic syndrome.