The polymorphism analysed by our group has only been explored in the work by Grarup et al. [20], who didn't find association with obesity but identified an haplotype consisting of the rare alleles of this SNP and the rs2076169 polymorphism, located upstream in the same LD block, that was associated with a greater insulin sensitivity. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.