The human ortholog of Ll, C1orf32, which is 90% identical to Ll at the amino acid level, maps to a region of Chr1q23 that has been implicated in T2D in seven ethnically diverse populations including Caucasians (Northern Europeans in Utah) [100], Amish Family Study [101],[102], United Kingdom Warren 2 study [103], French families [104], and Framingham Offspring study [105], Pima Indians [106], and Chinese [96] with LOD scores as high as 4.3. The gene discussed is ILDR2; the disease is type 2 diabetes mellitus.