In addition to major disturbance of phagocyte function, excessive C5a levels during sepsis have been linked to impaired myocardial contractility and cardiac output [26], profound coagulatory and fibrinolytic changes [27], and enhanced production of proinflammatory cytokines and chemokines [17], [28], all of which result in reduced survival in rodents. Here, C5AR1 is linked to Sepsis.