GEMS analysis [22], used to search for transcription factor binding sites (MatInspector) and sequence models (ModelInspector), of the –1682 to +1 region of the human IGF-1 promoter, revealed the presence of potential binding sites for several different transcription factors, including ets family members, supporting the possibility of direct interaction of Ewing's sarcoma fusion proteins with the IGF-1 promoter. This evidence concerns the gene IGF1 and Ewing sarcoma.