Taking a candidate gene approach, Kurreeman and colleagues [35] studied 40 SNPs in a 300 kb region surrounding C5 (from the 3′ UTR of PHF19 to intron 25 of CEP110) in a staged-approach in four sample sets (2,719 cases / 1999 controls) and concluded that rs10818488, another TRAF1-C5 intergenic SNP and member of the LD Block 1 Group 2 SNPs, was the SNP most significantly associated with a diagnosis of RA in their study. This evidence concerns the gene TRAF1 and rheumatoid arthritis.