The pairwise analyses of the combined datasets suggest there may be two independent statistical signals of association to RA at chr 9q33.2 – one in the TRAF1 region represented by rs7021049 and one in the GSN region represented by rs10985196 (Table 6); however, analyses of the individual sample sets showed rs10985196 was independently associated with disease risk in Sample Set 2 only while rs7021049 showed consistent association across all three sample sets (data not presented). The gene discussed is TRAF1; the disease is rheumatoid arthritis.