We have selected the Morris water maze task to address the possible abnormalities in spatial memory in Dyrk1A+/− mice to identify the roles of Dyrk1A. However, since previous studies [29] suggested that specific mental retardation models might be more responsive to potential stressors and more prone to swim-induced hypothermia, we have also tested our mice in a swimming test designed to determine the influence of the levels of aversiveness associated with the test. Here, DYRK1A is linked to Intellectual disability.