COP1 and lymphopenia: Based on the above findings in SOD1 Tg mice demonstrating a lack of protective response by COP-1 immunization in male mice, diminished T cell functional capacity in early symptomatic and late stage mice, and end stage lymphopenia, we tested a strategy to rectify the lymphoid dysregulation and extend survival by adoptive transfer of B6 Wt naïve lymphoid cells to recipient B6 SOD1 Tg mice.