The implication of macrophages and microglia in disease progression in ALS and SOD1 Tg mice [1], [8], [9], [68], [69] and evidence of Treg-mediated regulation of microglia function [21], [44], [70], suggest that Treg affect the induction phase of those cells. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.