Additionally, the CD45RA/CD45R0 (naïve/memory) ratio among CD4+ T cells of ALS patients (0.6±0.1) was diminished by 45% compared to caregivers (1.1±0.2, p = 0.028), which was due to the diminution in levels of CD45RA+ naïve T cell among CD4+ cells (37.2%±2.5% compared with 47.6%±5.1% for caregivers, p = 0.0435) and a concomitant increase in levels of CD45R0+ memory cells among CD4+ T cells (62.1%±2.6% compared with 51.7%±5.2% for caregivers, p = 0.0465). Here, CD4 is linked to amyotrophic lateral sclerosis.