The purpose of this study was to investigate the lysyl oxidase-like 1 (LOXL1) gene for SNP variations in Japanese patients with XFS including those with exfoliation glaucoma (XFG) and compare them to patients with primary open-angle glaucoma (POAG) as well as to examine the phenotypes of the patients with these variations. The gene discussed is LOXL1; the disease is exfoliation syndrome.