Six of the open-angle glaucoma loci are primarily associated with early onset open-angle glaucoma or JOAG: GLC1A, GLC1J, GLC1K, GLC1M, GLC1N, and a novel region on 2p15–16 that partially overlaps with GLC1H [12,13,15,26-28]. Here, MYOC is linked to open-angle glaucoma.