Myocilin (MYOC, GLC1A, OMIM 601652) is responsible for 20% of patients with JOAG [15] and 3%–5% of POAG, optineurin (OPTN, GLC1E, OMIM 602432) [16] is primarily associated with low tension glaucoma, and WD repeat domain 36 (WDR36, GLC1G, OMIM 609669) [17] may be a modifying factor that can influence the severity of disease [18]. Here, OPTN is linked to open-angle glaucoma.