These included TNFRSF12A, which is highly expressed in the dSSc patients and shows high expression in patients with increased MRSS (see Figure 6), WIF1, which shows low expression in SSc its decreased expression is associated with increased MRSS, and CD8A, which is highly expressed in CD8+ T cells and is highly expressed in the inflammatory subset of patients. This evidence concerns the gene TNFRSF12A and systemic sclerosis.