DNMT1 and amyloidosis: Among them, DNMT1 and DNMT3a showed epimutations of DNA methylation on the first exon, i.e., tissue-specific methylation of DNMT3a and age-specific methylation of DNMT1. Interestingly, the age-specific style shown by DNA methylation of DNMT1 may contribute to some forms of amyloidosis that develops with aging [42].