ITGB1 and immune system disorder: Consistent with the higher vRNA levels in CD4+ CM T cells of coinfected animals, 4 out of the 6 of these monkeys also had losses to abnormal levels (<10%) of the CD4+CD29+ subset of memory T-cells in peripheral blood, which is an early sign of immune dysfunction in lentivirus-infected-macaques [13],[20],[21].