Among the three pancreatic cancer cell lines used in this study, PANC-1 cells expressed the highest relative level of xCT mRNA compared with that of BxPC-3 and MIA PaCa-2 (Figure 5A), suggesting that PANC-1 cells may exhibit the greatest resistance towards oxidative stress-induced cell death. The gene discussed is SLC7A11; the disease is familial pancreatic carcinoma.