FAS and neoplasm: Upregulation of FasL expression is an early event in colon carcinogenesis (Bennett et al, 2001; Belluco et al, 2002), with tumour-expressed FasL being associated with apoptosis and loss of tumour-infiltrating lymphocytes (TIL) in vivo, and triggering the death of Fas-bearing sensitive cells in vitro (O’Connell et al, 1996; Okada et al, 2000).