Genes involved in that process were EDN1, GADD45A, IL1A, MT2A, PTHLH, REN, RRM2B, SERPINE1, THBS1, TGFB1, UPK2, and VEGF. Other highly significant functions were "cancer growth of tumor cell lines" (P = 1.99 × 10-7), and "cellular growth" and "proliferation" (colony formation of eukaryotic cells) (P = 5.94 × 10-7). Here, RRM2B is linked to neoplasm.