Genes involved in that process were EDN1, GADD45A, IL1A, MT2A, PTHLH, REN, RRM2B, SERPINE1, THBS1, TGFB1, UPK2, and VEGF. Other highly significant functions were "cancer growth of tumor cell lines" (P = 1.99 × 10-7), and "cellular growth" and "proliferation" (colony formation of eukaryotic cells) (P = 5.94 × 10-7). This evidence concerns the gene SERPINE1 and neoplasm.