PPARG and breast cancer: Describedassociations between PPARG polymorphisms and breast carcinoma are also discrepant: some researchers see amarginally significant increase in the risk of breast cancer among womenhomozygous for the Ala allele of PPARγ (Pro12Ala), causing a reduction in the transcriptional activityof PPARγ2 [35], while others stress that carriers of the same variant alleleare at lower risk [36].