Organ-specific autoimmune diseases, such as multiple sclerosis (MS) and itsanimal model, are mediated by IFN-γ and/or IL-17 producing CD4 T helper cells.Since PPAR-α regulates inflammation and cytokineproduction, PPAR-α agonists have been tested as apotential treatment for autoimmune diseases. This evidence concerns the gene PPARA and multiple sclerosis.