Lee et al. [22] reported that the PPAR-α agonist, Fenofibrate, repressed IL-17and interferon-gamma expression and improved colitis in IL-10-deficient mice.PPAR-α was found to be expressed inlymphocytes, macrophages, and crypt and surface epithelial cells of the colon.Colonic expression of interferon-gamma and IL-17 genes was decreased in IL-10deficient mice, when the mice were treated with fenofibrate. The gene discussed is PPARA; the disease is colitis.