Additionally, modulation of the Wnt/β-cateninsignalling pathway may also account for some PPARγ-mediatedbeneficial effects in AD since recent findings show that PPARγ-mediatedprotection of hippocampal neurons against Aβ-inducedtoxicity directly correlates with β-cateninlevels, inhibition of GSK-3β activity,and increased levels of Wnt-target genes [24, 60]. This evidence concerns the gene PPARG and Alzheimer disease.