In murine studies, CCL21-DC induced tumor regression, stimulated production of IFN-γ and the CXC chemokines MIG (CXCL9) and IP-10 (CXCL10) at the tumor site, and decreased local concentrations of immunosuppressive inflammatory mediators including IL-10, PGE2, and TGF-β [27,31]. The gene discussed is TGFB1; the disease is neoplasm.