FASLG and neoplasm: Due to the ability of exosomes to mediate a variety of immunological signals, it was proposed that at the beginning of the neoplastic process, tumor secreted exosomes selectively induce antigen-specific T cell apoptosis, through activating the T cell receptor, which in turn upregulates expression of Fas on the T cell, subsequently, the FasL molecule on the exosome induces apoptosis.