Multivariate analysis of all pretreatment variables, including Skp2 expression, p27Kip1 expression, age, tumor size, tumor grade, nodal status, and ER, PR and Her2/neu receptor expressions, showed that Skp2 expression (P = 0.002; odds ratio = 8.91) and young age (P = 0.034) were the strongest predictors for poor disease-free survival. Here, ESR1 is linked to neoplasm.