The results indicated that while treatment with 1,25D3 had practically no effect on non-diabetic rats, the same treatment in streptozotocin-induced diabetic rats corrected in part the over-expression of the IR gene in liver and adipose tissue, although it did not revert the hyperglycemia, hypoinsulinemia, glycosuria or ketonemia of these diabetic animals. The gene discussed is INSR; the disease is Hypoinsulinemia.