Zagaria et al [8] also reported two cases of CML patients with masked Ph and associated deletions: one patient with a cryptic ins(9;22) and a deletion of 5' ABL1 and 3' BCR regions; the other patient with a multi-step variant translocation and a deletion of around 400 Kb telomeric of the ABL1 gene. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.