GC and infection: The success of efficiently producing RVFV VLPs in insect cells and successfully recovering the VLPs from the culture media, together with the finding that the Gn and Gc proteins produced in recombinant Vaccinia virus and recombinant baculovirus efficiently trigger immune reactions in mice to lethal RVFV infections [22,24] indicate that the baculovirus-insect cells is a powerful system to produce large amount of RVFV VLPs for the purpose of vaccine production.