We found HDL (OR = 0.91 95%CI: 0.89–0.93, p < 0.0001), glycaemia (OR = 1.01 95%CI: 1.01–1.02, p < 0.0001), CAD history (OR = 2.14 95%CI: 1.36–3.35, p = 0.001), smoking habit (OR = 1.81 95%CI: 1.11–2.93, p = 0.017), dyslipidaemia (OR = 13.18, 95%CI: 8.32–22.14, p < 0.0001) and ACE I/D DD polymorphism (OR = 1.72, 95%CI: 1.08–2.75, p = 0.022) to be independently related to CAD. The gene discussed is ACE; the disease is coronary artery disorder.