The only significant results were found when associating the RAS combined set of alleles with the disease, where individuals under 45 have a 2.47 relative risk of CAD occurrence when in the join presence of ACE11860 G/ACE I/D D/AGT174 T/AGT235 T/AT1R A. Here we must point the impossibility to further subdivide this group according to sex, due to small sample size, as a limitation to perform a more thorough analysis. The gene discussed is ACE; the disease is coronary artery disorder.