The risk provided by obesity was found to be positively reinforced by AT1R CC in the whole population analysis and ACE I/D DD in all subgroups, particularly in females (SI = 2.82, SIM = 1.79; AP = 0.46) and ≥ 45 subgroup (SI = 4.13, SIM = 2.36, AP = 0.65). The gene discussed is ACE; the disease is obesity due to melanocortin 4 receptor deficiency.