Considering all genes involved in the RAS system, only five out of nineteen obtained combinations yielded significant associations with CAD (Table 3), especially a male driven decreased risk provided by the ACE11860 A/ACE I/D I/AGT174T/AGT235 M/AT1R A combination and an increased probability of early onset CAD provided by ACE11860 G/ACE I/D D/AGT174 T/AGT235T/AT1R A. This evidence concerns the gene ACE and coronary artery disorder.