LOXL1 and exfoliation syndrome: Thorleifsson et al. [7] reported that allele G was the risk allele of rs1048661 and rs3825942 for XFS, the (G, G) haplotype had the highest risk, and the risk G allele of rs1048661 was associated with low expression of LOXL1 mRNA, which suggests that low LOXL1 expression predisposes to XFS.