The top-scoring molecular network for the PGC comprised 11 PGC focus genes interacting either directly or indirectly with the well-known cancer-related transcription factors Myc and TP53 (p = 10−19, see Methods) (Figure S1), and the most significantly enriched cellular functions in the PGC were cancer (p<0.0045), tumor morphology (p<0.0045) and cell cycle control (p<0.0045). This evidence concerns the gene TP53 and cancer.