A closer look at the eight Ox-E/ER genes linked to these growth factors revealed that most (EGR1 [65], PHLDA1 [66], IGFBP5 [67,68], TAGLN [68], DAB2 [69], and FHL2 [70]) have been associated with breast cancer. The gene discussed is IGFBP5; the disease is breast carcinoma.