Although suppression of oxidant-repressed genes was not shown to be associated with ERBB2 over-expression, there was an enrichment of oxidant-induced genes among the ERBB2 over-expressing ER-positive breast tumors, suggesting that elevated oxidative stress is associated with ERBB2 overexpression and may contribute to the loss of PR co-expression seen in ERBB2 overexpressing ER-positive breast cancers. The gene discussed is ESR1; the disease is breast carcinoma.