EDN1 and metabolic syndrome: Healthy participants had, on average, greater increments in plasma levels of ET-1 after DE200 (Δ = 0.76; 95% CI, 0.38 to 1.1) compared with participants with metabolic syndrome (Δ = 0.31; 95% CI, 0.12 to 0.51) (p = 0.02).