Two polymorphisms in the IL4 (G/C 3′-UTR) and IL5 (C-703T) genes were studied in a sample of families whose probands had atopic bronchial asthma (BA) (66 families,n = 183) and in a group of non-cognate individuals with the severe form of the disease(n = 34). The gene discussed is IL4; the disease is breast angiosarcoma.