Furthermore, the SNRPN and D15S63 loci, whichare located in the imprinted region of chromosome 15, were included in the study.Aberrant methylation was detected in nine of 40 tumours analysed: The imprintedSNRPN and D15S63 loci were hypermethylated in three tumours, all of which retainedboth copies of chromosome 3. This evidence concerns the gene SNRPN and neoplasm.