In silico analysis of this fragment (http://www.cbrc.jp/research/db/TFSEARCH.html) revealed a putative binding site for the POU-domain transcription factor BRN2 at −50 to −36 relative to the transcription start site (Figure 2D), so we investigated the role of BRN2 in MITF regulation in melanoma cells. This evidence concerns the gene POU3F2 and melanoma.