Notably, of the 15 breast cancer patients with personal or family history of ovarian cancer, six had mutations in BRCA1 and two in BRCA2. In addition, of the 14 BRCA1 carriers and 14 BRCA2 carriers identified in this study, five had bilateral breast cancer (one synchronous and four metachronous). The gene discussed is BRCA1; the disease is breast carcinoma.