The G20210A variant in the 3' UTR of prothrombin gene (FII G20201A) is associated with higher plasma prothrombin activity and has a prevalence of 1.2–4.6% in the general Caucasian population, and higher in patients affected by venous thromboembolism (VTE, [1,2]). Here, F2 is linked to venous thromboembolism.