In conclusion, our cases support the idea that the G20210A homozygote genotype associated to another thrombotic risk factor acting as trigger factor is sufficient to give vascular complications as venous thromboembolism and\or female infertility [17,18]; moreover, inherited thrombophilia and in particular the prothrombin A20210G variant is a relevant risk factor for recurrent pregnancy loss. This evidence concerns the gene F2 and Rare hereditary thrombophilia.