B9L expression was also reduced after BCL9 depletion (which thus mimics a double knock-down of both paralogs, albeit a partial one) although the converse was not true, possibly because this gene is only mildly Wnt-inducible, and is less hyperactive than B9L in colorectal cancer cell lines (see Fig. 3). The gene discussed is BCL9L; the disease is colorectal cancer.