TPO and thyroid gland disorder: We observed that stimulation of PBMCs with CpG-B and IL-2 led to the production of IgG anti-thyroperoxidase and anti-cardiolipin antibodies from the majority of patients with thyroiditis (3 out of 4 patients) and anti-phosphoslipid antibody syndrome respectively (2 out of 3 patients) (Fig. 4).