Xu et al. [18] also reported that all RARs and RXRs were expressed in at least 89% of control normal bronchial tissue specimens from patients without a primary lung cancer and that in distant normal bronchus specimens from patients with NSCLC RARα, RXRα and γ were expressed in more than 95% of the tumor-free specimens. The gene discussed is RARS1; the disease is lung cancer.