The results showed that in only 18 months the levels of neurosin significantly increased (from 7.17 ng/ml to 8.79 ng/ml) in patients whose disease progressed to dementia with vascular component (p = 0.043) while the decrease in patients whose disease progressed to AD (from 4.96 ng/ml to 4.87 ng/ml) was not statistically significant (p = 0.747). Here, KLK6 is linked to dementia.