Therefore we investigated the role of the the -2221Msp(C/T) and -23HphI(A/T) insulin gene polymorphisms in patients with isolated T1D, AD and HT and in patients with a APS-II [T1D and/or AD and at least one of the disorders HT or GD] as well as in healthy controls (HC). This evidence concerns the gene INS and hematocrit.