For example, HO-1 protects retinal cells against light-induced damage [23], ameliorates ischemia-reperfusion injury elicited by a number of different conditions [24], inhibits endothelial cell apoptosis induced by endoplasmic reticulum stress [25], protects mice from apoptotic liver damage [26], prevents development of atherosclerosis in LDL-receptor knock-out mice [27], improves survival of transplanted organs [28] or prevents development of gastric ulcers in rats [29]. Here, HMOX1 is linked to gastric ulcer.