Heme-induced HO-1 expression protects against cyclophosphamide-mediated hemorrhagic cystitis [30], HO-1 attenuates cisplatin-induced toxicity in renal tubular cells [31] or in auditory cells [32], it also decreases doxorubicin-mediated cardiotoxicity [33]. The gene discussed is HMOX1; the disease is hemorrhagic cystitis.