PBX1 and acute lymphoblastic leukemia: The first one consists of at least six hotspots in the 218-kb long second intron of Pbx1 (pre B-cell leukemia transcription factor 1, located at 169.995–170.268 Mb, NCBI Build 36), which is also a hotspot for translocations associated with acute lymphoblastic leukemia in humans [36],[37].